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We are interested in taking single molecule measurements into living cells to study the organization, function, and dynamics of cellular processes.

Recent News

(December 2021) Our preprint “A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation” is now available on BioRxiv!

(December, 2021) Our preprint “Gene regulation network inference using k-nearest neighbor-based mutual information estimation-Revisiting an old DREAM” is now available on BioRxiv!

(August, 2021) Our preprint “FtsN activates septal cell wall synthesis by forming a processive complex with the septum-specific peptidoglycan synthase in E. coli” is now available on BioRxiv!

(August, 2021) Dr. Gina Wang’s paper “Protein detection in blood with single-molecule imaging” has been published in Science Advances!

(June, 2021) Biostatistics masters student Ziqi Fu joins the lab. Welcome Ziqi!

(June, 2021) Our paper “A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM” has been published in Nature Methods!

(June, 2021) An author profile on Dr. Jie Xiao been published in Nature Methods to accompany “A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM” !

(May, 2021) First year PMB student Martin Yepes joins the lab. Welcome Martin!

Select Publications

Weng X, Bohrer CH, Bettridge K, Lagda AC, Cagliero C, Jin DJ, Xiao J. Spatial organization of RNA polymerase and its relationship with transcription in Escherichia coli. Proc Natl Acad Sci U S A. 2019 Sep 16;. doi: 10.1073/pnas.1903968116

Yang X, Lyu Z, Miguel A, McQuillen R, Huang KC, Xiao J. GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis. Science. 2017 Feb 17;355(6326):744-747

Coltharp C, Buss J, Plumer TM, Xiao J. Defining the rate-limiting processes of bacterial cytokinesis. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1044-53

Buss J, Coltharp C, Shtengel G, Yang X, Hess H, Xiao J. A multi-layered protein network stabilizes the Escherichia coli FtsZ-ring and modulates constriction dynamics. PLoS Genet. 2015 Apr;11(4):e1005128

Hensel Z, Weng X, Lagda AC, Xiao J. Transcription-factor-mediated DNA looping probed by high-resolution, single-molecule imaging in live E. coli cells. PLoS Biol. 2013;11(6):e1001591

Hensel Z, Feng H, Han B, Hatem C, Wang J, Xiao J. Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis. Nat Struct Mol Biol. 2012 Aug;19(8):797-802