Ecoli3The overall objective of our research is to study the dynamics of cellular processes as they occur in real time at the single-molecule and single-cell level. The depth and breadth of our research require an interdisciplinary approach, combining biological, biochemical and biophysical methods to address compelling biological problems quantitatively. With unprecedented sensitivities to detect individual molecules, the use of single-molecule and single-cell approaches allows one to access information that is not readily available to traditional ensemble measurements. We are currently focusing on the following projects: