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We are interested in taking single molecule measurements into living cells to study the organization, function, and dynamics of cellular processes.

Recent News

(Sept, 2019) Ever dealt with fluorophore blinking in superresolution microscopy? It is worse than you think! Check out Chris Bohrer’s DDC algorithm to give you peace of mind. Now posted in BioRxiv.

(Sept, 2019) Xiaoli Weng’s paper on the spatial organization of RNA polymerase publishes in PNAS. Congratulations Xiaoli!

(Sept, 2019) Chris Bohrer gives a talk on his DDC algorithm at IBR retreat.

(Sept, 2019) Hopkins sophomore Hunter Hendrix joins the Xiao lab for undergraduate research. Welcome Hunter!

(Aug, 2019) Super Z-ring group meeting at Marion, MA. Fun and science-packed three days!

(July, 2019) SUSTECH senior Yao Tu joins the Xiao lab for summer research internship. Welcome Yao!

(June, 2019) U. Michigan senior Eric Donarski joins the Xiao lab for summer research internship. Welcome Eric!

(May, 2019) First year PMB student Nicolas Yehya joins the lab. Welcome Nico!

 

 

 

 

 

Upcoming Events

Select Publications

Weng X, Bohrer CH, Bettridge K, Lagda AC, Cagliero C, Jin DJ, Xiao J. Spatial organization of RNA polymerase and its relationship with transcription in Escherichia coli. Proc Natl Acad Sci U S A. 2019 Sep 16;. doi: 10.1073/pnas.1903968116

Yang X, Lyu Z, Miguel A, McQuillen R, Huang KC, Xiao J. GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis. Science. 2017 Feb 17;355(6326):744-747

Coltharp C, Buss J, Plumer TM, Xiao J. Defining the rate-limiting processes of bacterial cytokinesis. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1044-53

Buss J, Coltharp C, Shtengel G, Yang X, Hess H, Xiao J. A multi-layered protein network stabilizes the Escherichia coli FtsZ-ring and modulates constriction dynamics. PLoS Genet. 2015 Apr;11(4):e1005128

Hensel Z, Weng X, Lagda AC, Xiao J. Transcription-factor-mediated DNA looping probed by high-resolution, single-molecule imaging in live E. coli cells. PLoS Biol. 2013;11(6):e1001591

Hensel Z, Feng H, Han B, Hatem C, Wang J, Xiao J. Stochastic expression dynamics of a transcription factor revealed by single-molecule noise analysis. Nat Struct Mol Biol. 2012 Aug;19(8):797-802