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We are interested in taking single molecule measurements into living cells to study the organization, function, and dynamics of cellular processes.

Recent News

(September 5, 2018) Towson High school student Alice Liao joins the Xiao lab for her internship program. Welcome back Alice!

(September 1st, 2018) Jie and collaborator Elijah Roberts receive NSF funding to study gene regulation by chromosomal topological organization in E. coli.

(August 28 – September 1st, 2018) Kelsey presents research at Cold Spring Harbor Single Molecule Meeting, NY.

(August 25, 2018) End-of-the-summer pool party at Jie’s house.

(August 12-17, 2018) Xinxing and Jason present research at GRC Plant and Microbial Cytoskeleton, Andover, NH.

(August 13, 2018) Jie gives talk at GRC Plant and Microbial Cytoskeleton, Andover, NH.

(July 15-20, 2018) Xinxing, Jason and Gina present research at GRC Single Molecule Approaches to Biology, West Dover, VT.

(July 17, 2018) Jie gives talk at GRC Microbial Stress Responses, South Hadley, MA.

(July, 2018) Undergraduate students Yiwen Zhang from Peking University and Yiyan Lin from SUSTech university join the Xiao lab for summer research. Welcome Yiwen and Yiyan!

(June 9, 2018) Jie gives talk at annual Microbe meeting of American Society for Microbiology, Atlanta, GA.

(May 18, 2018) First year PMB student Drew Morley joins the Xiao lab. Welcome aboard Drew!

(May 12, 2018) Xiao lab atends the 3rd Chesapeake Bay Area Single Molecule Biology Meeting at Homewood campus, Johns Hopkins University.

(April 27, 2018) Jie gives student-invited seminar at Quantitative and Chemical Biology (QCB) Graduate Training Program at Indiana University, Bloomington.

(April 21, 2018) Ryan gives talk at Spotlight session at Annual Meeting of American Society for Biochemistry and Molecular Biology, San Diego, CA.

(April 14, 2018) Jie gives talk at the annual workshop on the Physical Basis on Cellular Memory and Adaptation, Barbados.

(April 13, 2018) Jie gives talk at Microbiology Society Annual Conference, Birmingham, U.K.

(March 20, 2018)  Jie gives talk at NIH LMIG seminar.

Past News and Events

Upcoming Events

(September 25, 2018) Jie gives talk at Department of Biological Chemistry, University of Michigan, Ann Harbor, IL.

(September 9 – 12, 2018) Chris gives talk at Single-Molecule Bacteriology at 84th Harden Conference, Biochemical Society, Oxford University, U.K.

Select Publications

Yang, X., Lyu, Z., Miguel, A., McQuillen, R., Huang, K.C., and Xiao, J., GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis. Science, 2017. 355(6326): p. 744-747.

Coltharp, C., Buss, J., Plumer, T.M., and Xiao, J., Defining the rate-limiting processes of bacterial cytokinesis. PNAS, 2016. 113(8): p. E1044-53.

Buss J, Coltharp C., Shtengel G, Yang X, Hess H and Xiao J., Al multi-layered protein network maintains the stability of the FtsZ-ring and modulate constriction dynamics in E. coli, PLoS Genetics, 2015, Apr 7;11(4):e1005128.

Hensel Z.,Weng X., Lagda A., Xiao J., Transcription factor mediated DNA looping probed by high-resolution, single-molecule imaging in live E. coli cells, 2013, PLoS Biology, 11(6): e1001591.

Hensel Z., Feng H., Han B., Hatem C., Wang J., Xiao J., Stochastic expression dynamics of transcription factor revealed by single-molecule noise analysis, Nat. Struct. Mol. Biol. 2012,

Guo F., Huang T., Buss J., Coltharp C., Hensel Z., Xiao J., In vivo structure of the E. coli FtsZ-ring revealed by photoactivated Localization Microscopy (PALM), PLoS One, 2010, 5, e12680.