We are interested in taking single molecule measurements into living cells to study the organization, function, and dynamics of cellular processes.

Recent News

(Sept, 2019) Ever dealt with fluorophore blinking in superresolution microscopy? It is worse than you think! Check out Chris Bohrer’s DDC algorithm to give you peace of mind. Now posted in BioRxiv.

(Sept, 2019) Xiaoli Weng’s paper on the spatial organization of RNA polymerase publishes in PNAS. Congratulations Xiaoli!

(Sept, 2019) Hopkins sophomore Hunter Hendrix joins the Xiao lab for undergraduate research. Welcome Hunter!

(Aug, 2019) Super Z-ring group meeting at Marion, MA. Fun and science-packed three days!

(July, 2019) SUSTECH senior Yao Tu joins the Xiao lab for summer research internship. Welcome Yao!

(June, 2019) U. Michigan senior Eric Donarski joins the Xiao lab for summer research internship. Welcome Eric!

(May, 2019) First year PMB student Nicolas Yehya joins the lab. Welcome Nico!






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Select Publications

Yang, X., Lyu, Z., Miguel, A., McQuillen, R., Huang, K.C., and Xiao, J., GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis. Science, 2017. 355(6326): p. 744-747.

Coltharp, C., Buss, J., Plumer, T.M., and Xiao, J., Defining the rate-limiting processes of bacterial cytokinesis. PNAS, 2016. 113(8): p. E1044-53.

Buss J, Coltharp C., Shtengel G, Yang X, Hess H and Xiao J., Al multi-layered protein network maintains the stability of the FtsZ-ring and modulate constriction dynamics in E. coli, PLoS Genetics, 2015, Apr 7;11(4):e1005128.

Hensel Z.,Weng X., Lagda A., Xiao J., Transcription factor mediated DNA looping probed by high-resolution, single-molecule imaging in live E. coli cells, 2013, PLoS Biology, 11(6): e1001591.

Hensel Z., Feng H., Han B., Hatem C., Wang J., Xiao J., Stochastic expression dynamics of transcription factor revealed by single-molecule noise analysis, Nat. Struct. Mol. Biol. 2012,

Guo F., Huang T., Buss J., Coltharp C., Hensel Z., Xiao J., In vivo structure of the E. coli FtsZ-ring revealed by photoactivated Localization Microscopy (PALM), PLoS One, 2010, 5, e12680.